Obagi Refissa Tretinoin Cream 0.05 % 20g Expiration: March 2012 SUNBLOCK MUST BE WORN WHEN USING TRETINOIN Refissa Tretinoin Cream is a serious medication that helps treat but will not cure fine wrinkles, spotty skin discoloration, and rough feeling skin. Refissa REFISSA: â Diminishes fine facial wrinkles. â Fades irregular pigmentation due to sun damage. â Smoothes the skin so itâs softer to the touch (tactile roughness). â Clinically proven to be effective and itâs approved by the FDA. â Only 0.05% strong prescription tretinoin cream thatâs fragrance-free with a moisturizing, emollient base. WARNING: â Do not use if you are pregnant, attempting pregnancy, or nursing. â Do not use if sunburned or has eczema or other chronic skin conditions. â Do not us if inherently sensitive to sunlight. â Do not use if taking drugs known to be photosensitizers (e.g. thiasides, tetracyclines, fluoroquinolones, phenothiazines, sulfonamides) because of the possibility of augmented phototoxicity. Â