Refissa Tretinoin Cream is a fragrance free, emollient treatment that contains 0.05% Tretinoin, a derivative of vitamin A, that works deep at the skin’s cellular level. Obagi Refissa Tretinoin Cream is approved by the FDA and is clinically proven to be effective for melasma, facial wrinkles, rough skin, as well as deep and stubborn pigmentation. This is the only 0.05% strong prescription Tretinoin cream on the market, that is fragrance-free with a moisturizing, emollient base. Please consult skin care professional before using this product.