Short description Hepatoprotective agent. Capsule appearance: hard gelatin capsules, size "2", brown body and cap. Appearance of the capsule contents: yellow powder. pharmachologic effect It interacts with free radicals in the liver and converts them into less toxic compounds, interrupting the process of lipid peroxidation, and prevents the destruction of cellular structures. In damaged hepatocytes, it stimulates the synthesis of structural and functional proteins and phospholipids (due to specific stimulation of RNA polymerase A), stabilizes cell membranes, prevents the loss of cell components (transaminases), and accelerates the regeneration of liver cells. It inhibits the penetration of some hepatotoxic substances into the cell. Pharmacokinetics Absorption - low and slow (half-absorption period - 2.2 hours), metabolized in the liver by conjugation, half-life - 6 hours. It is excreted mainly in the bile in the form of glucuronides and sulfates. Does not accumulate in the body. Intestinal-hepatic circulation is noted. Indications Toxic liver damage (alcoholism; intoxication with halogenated hydrocarbons, heavy metal compounds; medicinal liver damage) and their prevention. Method of administration and dosage Inside, after meals, with a little water. 2 capsules 3 times a day. Maintenance dose - 1 capsule 3 times a day. Side effects Allergic reactions, rarely a laxative effect. Contraindications Hypersensitivity to the components of the drug. APPLICATION DURING PREGNANCY AND BREASTFEEDING It is not recommended to use the drug during pregnancy and breastfeeding. Interaction with other drugs Not described. Structure Active ingredient: milk thistle fruit extract dry (36-44: 1) - 86.5-93.35 mg, equivalent to 70 mg of silymarin (DNPH), equivalent to 54.1 mg of silymarin (HPLC / DF) calculated on silibinin. Excipients: polysorbate 80, povidone, mannitol, sodium carboxymethyl starch (type A), magnesium stearate. Shell: hard gelatin capsule, size "2", which includes: gelatin, iron dye red oxide (E172), titanium dioxide (E171), sodium lauryl sulfate, iron dye black oxide (E172). Storage conditions Store in a dark place at a temperature not exceeding +30 C. Keep out of the reach of children. The shelf life is 5 years. Do not use after the expiration date printed on the package.