Short description Pharmacological action - hepatoprotective. Acute and chronic liver diseases, accompanied by hyperammonemia; hepatic encephalopathy (latent and severe), incl. as part of complex therapy for impaired consciousness (precoma or coma); parenteral nutrition of patients with protein deficiency. Inside, after meals, 1 sachet of granulate, previously dissolved in 200 ml of liquid, 2-3 times a day. pharmachologic effect Has a detoxifying effect, reducing the increased level of ammonia in the body, in particular, in liver diseases. The action of the drug is associated with its participation in the ornithine cycle of Krebs urea formation (activates the cycle, restoring the activity of liver cell enzymes - ornithine carbamoyltransferase and carbamoyl phosphate synthetase). Promotes the production of insulin and growth hormone. Improves protein metabolism in diseases requiring parenteral nutrition. It helps to reduce asthenic, dyspeptic and pain syndromes, as well as normalize increased body weight (with steatosis and steatohepatitis). Indications - acute and chronic liver diseases accompanied by hyperammonemia; - hepatic encephalopathy (latent or severe); - steatosis and steatohepatitis of various origins. Method of administration and dosage The drug is taken orally, 1-2 sachets of granules, dissolved in 200 ml of liquid, 3 times / day, after meals. The duration of the course depends on the severity of the disease. Side effects From the digestive system: infrequently - nausea, vomiting, abdominal pain, flatulence, diarrhea. From the musculoskeletal system: very rarely - pain in the limbs. Sunset yellow dye can cause allergic reactions. Contraindications - severe renal failure (serum creatinine 3 mg / 100 ml); - lactation period; - children's age (due to insufficient data); - hypersensitivity to the components of the drug. The drug should be prescribed with caution during pregnancy. Overdose Symptoms: increased severity of side effects. Treatment: gastric lavage, intake of activated charcoal, symptomatic therapy. special instructions Influence on the ability to drive vehicles and control mechanisms When establishing the diagnosis of hepatic encephalopathy due to the underlying disease, patients should be careful when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions. Interaction with other drugs Interaction with other medicinal products has not been described. Structure 5g of granules contain: Active substance: L-ornithine-L-aspartate 3g Excipients: citric acid anhydrous 0.55 g, lemon flavoring 0.02 g, orange flavor 0.2 g, sodium saccharinate (sodium saccharin) 0.0045 g, sodium cyclomate 0.0405 g, dye solar sunset yellow 0.0005 g, polyvinylpyrrolidone (povidone) 0.05 g, fructose (levulose) 1.1345 g. Storage conditions The drug should be stored out of the reach of children at a temperature not exceeding 25 C. The shelf life is 5 years.