125ml Vitiligo Organics Depigmentation Skin Repair. Made in Australia. Like other modern, pharmaceutical preparations, this medicine and its active ingredients are backed by science, including several human clinical trials. Benefits: - Suppressing immune cells(25) thought to be active in spreading vitiligo within the skin(30) - Quenching excess hydrogen peroxide, a by-product of melanin production that contributes to melanocyte death - Promoting the growth of melanocytes and Stimulating melanin production - These combined activities can help to normalise skin biology and to restore normal, healthy pigmentation. Main ingredients Psoralen: Purified forms of this substance are used as part of conventional photochemotherapy. Psoralen has a temporary photo-sensitizing effect, promoting melanin dispersal and increasing the number of melanocytes and Importantly, it suppresses the Langerhans cells. Psoralen is limiting cellular damage and decline by quenching reactive oxygen species; suppressing inflammation by interacting with pro-inflammatory cytokines and suppressing inflammation signaling processes, and promoting melanin production and normalizing immune responses; Berberis Vulgaris: neutralizing the hydrogen peroxide that contributes to the destruction of melanocytes, promoting the renewal and development of melanocytes, and for stimulating melanin production and Stimulating tyrosinase, a key enzyme required to transform tyrosine into melanin. Thymoquinone is widely regarded as being the biologically active component of Nigella Sativa. It has a dual action in the remediation of vitiligo It has potent antioxidant effects that help to suppress oxidative stress, and It can trigger a multi-step, biochemical pathway, that has a stimulatory effect on melanin production, as has been demonstrated in animals. Virgin Coconut Oil: Promote enhanced skin cell renewal; histopathological examination demonstrates an increase in fibroblast proliferation and neovascularization compared to controls, and Are effective at reducing hydrogen-peroxide mitigated cell death; Application Instruction: Shake well before use; Immerse bottle in a warm bowl of water until liquefied; Wash the affected area; Apply generously and massage into the skin every day and night before bed; Leave it on without rinsing for 8-10 hours; Lotion solidifies in cold weather; Tips for better results: EXFOLIATE Exfoliate the skin (remove dead skin cells from the outermost surface of the skin) that will help better absorption of lotion. (Deeper absorption = Greater results); DEEP MASSAGE Apply generously and deep massage with fingertips for 1-2 minutes every night before going to bed. Repeat in the morning preferably without washing off the night application; SUN EXPOSURE Sun exposure is not necessary but recommended in the morning for about 20-30 minutes for stimulation of pigments. If exposure to morning sunlight is not possible, UVB lamp can also be used as an alternative; VITAMINS People with vitiligo generally found deficient in some vitamins like B12, B9 (Folic Acid) and D3. You may consider adding these vitamins and Ginkgo Biloba to your daily diet; MOISTURIZER Keep your skin moisturized by applying natural moisturizer during the day when you are not wearing Vitiligo Organics WATER Daily intake of 1-2 liters of water is also recommended;