Ray Liotta .... Eugene 'Gino' Luciano
Tom Hulce .... Dominick 'Nicky' Luciano
Jamie Lee Curtis .... Jennifer Reston
Jack Boslet .... Teen #1
Mimi Cecchini .... Mrs. Gianelli
Vincent Cinese .... Teen #3
Bill Cobbs .... Jesse Johnson
Victoria Dym .... Woman (voice)
Todd Graff .... Larry Higgins
Lauren Harms .... Joey
Lindsay Harms .... Joey
Jacqueline Knapp .... Mrs. Vinson
Daniel Krell .... Lew
Raymond Laine .... Lt. Gage
Robert Levine .... Dr. Levinson
Joe Marmo .... Vince
Joe Maruzzo .... Guido
John Naples Jr. .... Abe
Mary-Joan Negro .... Theresa Chernak
Bingo O'Malley .... Perry
R. Scott Peck .... Joe
David Perry .... Television Announcer
Amanda Picciafoco .... Joey
Megan Picciafoco .... Joey
Matthew J. Ravenstahl .... Teen #2
Thomas Rocco .... Lew
John Romer .... Choir Director
Tom Signorelli .... Father T
Tommy Snelsire .... Mikey Chernak
David Strathairn .... Martin Chernak
Charles Susan .... Leon
Mel Winkler .... Neighbor Boy

Dominick and Eugene are twins, but Dominick is a little bit slow due do an accident in his youth. They live together, with Dominick working as garbage man to put Eugene through medical school. Their relationship becomes strained when Eugene must decide between his devotion to his brother, or his need to go away to complete his training. Things are also not helped by Dominick's co-worker, or Eugene's budding romance.

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