Thomas Jane .... Carter Blake
Saffron Burrows .... Dr. Susan McCallister
LL Cool J .... Sherman 'Preacher' Dudley
Michael Rapaport .... Tom Scoggins
Stellan Skarsgård .... Jim Whitlock
Samuel L. Jackson .... Russell Franklin
Jacqueline McKenzie .... Janice Higgins
Aida Turturro .... Brenda Kerns
Cristos .... Boat Captain
Daniel Rey .... Helicopter Pilot (as Daniel Bahimo Rey)
Valente Rodriguez .... Helicopter Co-Pilot
Brent Roam .... Helicopter Winch Operator
Eyal Podell .... Boy #1
Erinn Bartlett .... Girl #1
Dan Thiel .... Kevin Crawford
Sabrina Geerinckx .... Girl #2
Tajsha Thomas .... Friend of Janice
Frank Welker .... Parrot Noises (voice) (as Frank W. Welker)
Mary Kay Bergman .... The Parrot (voice) (uncredited)
Ronny Cox .... Executive (uncredited)
Renny Harlin .... Worker (uncredited)
Sarah Kelly .... Shark Victim (uncredited)

Samual L Jackson plays a businessman who sinks $200 million into a special project to help fight brain cancer. As part of this project, medical biologist Susan McAlester (Saffron Burrows) rather naughtily figures out a way to genetically embiggen shark brains, so that cancer-battling enzymes can be harvested. However, the shark subjects become super smart and decide they don't much like being cooped up in pens and being stabbed with hypodermics, so they figure a way to break out and make for the open sea...

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